Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of three subunits - troponin I, T, and C, and it plays a crucial role in muscle activity, connecting changes in intracellular Ca2+ concentration with generation of contraction. In spite of more than 40 years of studies, many aspects of troponin functioning are still not completely understood, and several models describing the mechanism of muscle contraction exist. Being a key factor in the regulation of cardiac muscle contraction, troponin complex is utilized in medicine as a target for some cardiotonic drugs used in the treatment of heart failure. A number of mutations in troponin subunits are associated with development of different types of cardiomyopathy. Moreover, for the last 25 years cardiac isoforms of troponin I and T have been widely used for immunochemical diagnostics of pathologies associated with cardiomyocyte death (myocardial infarction, myocardial trauma, and others). This review summarizes the existing evidence on the structure and function of troponin complex subunits, their role in the regulation of cardiac muscle contraction, and their clinical applications.
Takeda S. Takeda S. J Electron Microsc (Tokyo). 2005;54 Suppl 1:i35-41. doi: 10.1093/jmicro/54.suppl_1.i35. J Electron Microsc (Tokyo). 2005. PMID: 16157639
Liou YM, Chang JC. Liou YM, et al. J Biochem. 2004 Nov;136(5):683-92. doi: 10.1093/jb/mvh175. J Biochem. 2004. PMID: 15632309
Marston SB, Redwood CS. Marston SB, et al. Circ Res. 2003 Dec 12;93(12):1170-8. doi: 10.1161/01.RES.0000105088.06696.17. Circ Res. 2003. PMID: 14670832 Review.
Li MX, Spyracopoulos L, Sykes BD. Li MX, et al. Biochemistry. 1999 Jun 29;38(26):8289-98. doi: 10.1021/bi9901679. Biochemistry. 1999. PMID: 10387074
Sorsa T, Pollesello P, Solaro RJ. Sorsa T, et al. Mol Cell Biochem. 2004 Nov;266(1-2):87-107. doi: 10.1023/b:mcbi.0000049141.37823.19. Mol Cell Biochem. 2004. PMID: 15646030 Review.
Ragusa R, Caselli C. Ragusa R, et al. Genes Dis. 2024 Mar 11;11(6):101263. doi: 10.1016/j.gendis.2024.101263. eCollection 2024 Nov. Genes Dis. 2024. PMID: 39211905 Free PMC article. Review.
Elezaby A, Lin AJ, Vijayan V, Pokhrel S, Kraemer BR, Bechara LRG, Larus I, Sun J, Baena V, Syed ZA, Murphy E, Glancy B, Ostberg NP, Queliconi BB, Campos JC, Ferreira JCB, Haileselassie B, Mochly-Rosen D. Elezaby A, et al. Nat Cardiovasc Res. 2024 Aug;3(8):987-1002. doi: 10.1038/s44161-024-00512-1. Epub 2024 Jul 18. Nat Cardiovasc Res. 2024. PMID: 39196031
Bakoš M, Braovac D, Potkonjak AM, Svaguša T, Ćaleta T, Dilber D, Bartoniček D, Filipović-Grčić B, Galić S, Vrančić AL, Vogrinc Ž, Đurić Ž, Planinc M, Novak M, Matić T. Bakoš M, et al. Rev Cardiovasc Med. 2023 May 18;24(5):147. doi: 10.31083/j.rcm2405147. eCollection 2023 May. Rev Cardiovasc Med. 2023. PMID: 39076753 Free PMC article.
Guo J, Jiang H, Schuftan D, Moreno JD, Ramahdita G, Aryan L, Bhagavan D, Silva J, Huebsch N. Guo J, et al. iScience. 2024 May 10;27(6):109954. doi: 10.1016/j.isci.2024.109954. eCollection 2024 Jun 21. iScience. 2024. PMID: 38827401 Free PMC article.
Arifulin EA, Sheval EV. Arifulin EA, et al. Int J Mol Sci. 2024 Mar 8;25(6):3117. doi: 10.3390/ijms25063117. Int J Mol Sci. 2024. PMID: 38542091 Free PMC article. Review.